Monoclonal antibodies against lymphoma-associated antigens, hybr

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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5303881, 5303873, 5303888, C12N 512, C07K 1528, C12P 2108

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active

051697750

ABSTRACT:
The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are preferentially reactive with canine lymphoma cells and insignificantly reactive with normal canine lymphocytes.

REFERENCES:
patent: 4444744 (1984-04-01), Goldenberg
Sun, L. K. et al., Hybridoma, 5(Suppl):517-520, 1986.
Sarmiento, U. M. et al., Can J Vet Res., 51:110-116, 1987.
Appelbaum, et al., "Phenotyping of Canine Lymphoma with Monoclonal Antibodies Directed at Cell Surface Antigens: Classification, Morphology, Clinical Presentation and Response to Chemotherapy," Hematological Oncology, vol. 2, 151-168 (1984).
Krawiec, et al., "Development and Characterization of a Hybridoma-Derived Antibody (Aby 1A1) With Specificity to Canine Thymocytes and Peripheral T Lymphocytes," Am. J. Vet. Res., vol. 45, No. 3, 491-498.
Wulff, et al., "A Monoclonal Antibody (DT-2) Recognizing Canine T Lymphocytes," Transplantation, vol. 33, No. 4, 616-620 (1982).
Deeg, et al., "Unusual Distribution of Ia-Like Antigens on Canine Lymphocytes," Immunogenetics, vol. 16, 445-457 (1982).
Ladiges, et al., "Monoclonal Antibodies to Canine Cell Surface Antigens: A Comparison of Screening Assays," Hybridoma, vol. 3, No. 4, 387-390 (1984).
McKenzie, et al., "Studies With a Monoclonal Antibody on the Distribution of Thy-1 in the Lymphoid and Extracellular Connective Tissues of the Dog," Transplantation, vol. 31, No. 4, 275-282 (1981).
Schuenig et al., "Failure of Autologous Marrow Reconstitution After Cytolytic Treatment with Anti-Ia Monoclonal Antibody," Exp. Hematology (1984), vol. 12, 423, Abstract No. 168.

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