Method for inhibiting myocardial cell necrosis and preserving he

Details Method for inhibiting myocardial cell necrosis and preserving he Method for inhibiting myocardial cell necrosis and preserving he

1991-10-29

1993-10-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

052566889

ABSTRACT:
A method is provided for inhibiting myocardial cell necrosis and improving myocardial function during myocardial ischemia and/or reperfusion by locally administering to the heart a potent potassium channel activator such as pinacidil or cromakalim.

REFERENCES:
G. J. Gross et al, Journal of Cardiov. Pharm., 10 (Suppl. 8): S76-S84 (1987).
Norio Taira, Jounral of Cardiov. Pharm., 10 (Suppl. 8): S1-S9 (1987).
Naoaki Imai et al, Circulation, vol. 77, No. 3, Mar. 1988, pp. 705-710.
Nigel S. Cook, TIPS, Jan. 1988 (vol. 9) pp. 21-28.
Sakamoto et al, CA 105:91027q (1986).
Sakamoto et al, J. Nihon Univ. Med. Ass., vol. 45, No. 4, ppp. 299-307, 1986.

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