Substituted 2-aminotetralins and pharmaceutical use

Details Substituted 2-aminotetralins and pharmaceutical use Substituted 2-aminotetralins and pharmaceutical use

1992-09-28

1993-10-26

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 514259, 514261, 514299, 514300, 514306, 514311, 514359, 514364, 514367, 514375, 514406, 514415, 514443, 514456, 514469, 544235, 544237, 544277, 544283, 544353, 546112, 546117, 546122, 546138, 546174, 546176, 548126, 548152, 548179, 548180, 548217, 548257, 548260, 548261, 5483625, 548504, 549 43, 549 49, 549 58, 549407, 549467, A61K 4308, A61K 4310, A61K 4338, A61K 4342

Patent

active

052566617

ABSTRACT:
Certain novel compounds having the structural formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of hydrocarbyl radicals, e.g. lower alkyl radicals, i.e. methyl, ethyl, propyl, etc., or ##STR2## wherein R.sub.5 is selected from the group consisting of hydrocarbyl radicals, e.g. alkyl and aromatic residues; n is 2 or 3; and R.sub.1 is selected from the group consisting of organic radicals having fused aromatic rings, that is, radicals comprising at least two rings that share a pair of carbon atoms or share a carbon and nitrogen atom are useful for inducing a dopaminergic response and reducing the intraocular pressure in a mammal.

REFERENCES:
patent: 4564628 (1986-01-01), Horn
patent: 4657925 (1987-04-01), Horn
patent: 4722933 (1988-02-01), Horn
patent: 4743618 (1988-05-01), Horn
patent: 4882352 (1989-11-01), Horn
patent: 4996226 (1991-02-01), Horn

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