Method of preparing the enantiomers of O-dimethyltramadol

Details Method of preparing the enantiomers of O-dimethyltramadol Method of preparing the enantiomers of O-dimethyltramadol

1997-01-17

1998-03-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564302, 564443, C07C20988

Patent

active

057288852

ABSTRACT:
A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.

REFERENCES:
patent: 3652589 (1972-03-01), Flick et al.
patent: 5468744 (1995-11-01), Raffe et al.
Jacques et al., Enantiomers, Racemates and Resolutions,, 1991, Krieger Publishing Company, Malabar, Florida, pp. 259-261 and pp. 387-388.
Winterfeldt, "Applications of Diisobutylaluminium Hydryde (DIBAH) and Triisobutylaluminium (TIBA) as Reducing Agents in Organic Synthesis", Synthesis, Oct. 1975, pp. 617-630.
Sevcik et al., "Effects of the Central Analgesic Tramadol and Its Main Metabolite, O-desmethyltramadol, on Rate Locus Coeruleus Neurons", Chemical Abstracts, vol. 119, No. 25, Dec. 20, 1993, Abstract No. 262330.
Dayer et al., "The Pharmacology of Tramadol", Chemical Abstracts, vol. 121, No. 19, Nov. 7, 1994, Abstract No. 220754.
Flick et al., "Untersuchungen zur chemischen Struktur und analgetischen Wirkung von phenylsubstitutierten Aminomethylcyclohexanolen", Arzneimittel Forschung--Drug Research, vol. 28, No. 1a, Jan. 1, 1978, pp. 107-113.
Frankus et al., "Uber die Isomerentrennung, Strukturaufklarung und pharmakologische Charakterisierung von 1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-o1", Arzneimittel Forschung--Drug Research, vol. 28, No. 1A, (1978), pp. 114-121.

Affiliated with

Also associated with

Rating

Method of preparing the enantiomers of O-dimethyltramadol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing the enantiomers of O-dimethyltramadol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing the enantiomers of O-dimethyltramadol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-959223