Methods and compositions for inhibiting platelet aggregation

Details Methods and compositions for inhibiting platelet aggregation Methods and compositions for inhibiting platelet aggregation

1991-03-27

1993-10-26

Chan, Y. Christina

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, 514 12, 514 13, 514 14, 514 15, 514 16, 424 858, 530324, 530325, 530326, 530327, 530328, C12N 506, A61K 3702, A61K 39395, C07K 706

Patent

active

052565599

ABSTRACT:
This invention relates to anticoagulant and platelet inhibitory compositions, combinations and methods characterized by biologically active peptides which display the anticoagulant and platelet inhibitory activities of hirudin, or analogs thereof, for therapeutic and prophylactic purposes. The methods, compositions and combinations of this invention are advantageously useful for decreasing or preventing platelet aggregation and platelet activation in a patient or a biological sample. These methods, compositions and combinations are particularly useful in patients for whom standard heparin therapy is contraindicated due to a history of heparin-induced thrombocytopenia or an antithrombin III deficiency. This invention also relates to methods, compositions and combinations for treating extracorporeal blood and for increasing platelet storage life.

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