Pharmaceuticals for the treatment of rejection reactions in orga

Details Pharmaceuticals for the treatment of rejection reactions in orga Pharmaceuticals for the treatment of rejection reactions in orga

1992-08-20

1998-03-17

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514626, 514885, A61K 3142, A61K 3116

Patent

active

057287210

ABSTRACT:
The use of compound 1 and/or 2 of the formulae ##STR1## and of physiologically tolerable salts of compound 2 for the treatment of rejection reactions of the organ recipient to the transplanted organ is described.

REFERENCES:
patent: 4061767 (1977-12-01), Ertel et al.
patent: 4284786 (1981-08-01), Kammerer et al.
patent: 4965276 (1990-10-01), Bartlett et al.
C.C.A. Kuchle et al., "Prevention of Kidney and Skin Graft Rejection Rates by Leflunomide, a New Immunolodulaitng Agent," Transplantation Proceedings, vol. 23, No. 1 (Feb. 1991), pp. 1083-1086.
D.B.J. Herrmann et al., "Drugs in Autoimmune Diseases," Klinische Wochenschrift, vol. 68 (Suppl. XXI) (1990), pp. 15-25.
K. Ulrichs et al., "Suppression of Natural Xenophile Antibodies with the Novel Immunomodulating Drug Leflunomide," Transplantation Proceedings, vol. 24, No. 2 (Apr. 1992), pp. 718-719.
R.R. Bartlett, et al., "Leflunomide (HWA 486), a Novel Immunomodulating Compound for the Treatment of Autoimmune Disorders and Reactions Leading to Transplantation Rejection," Agents and Actions, vol. 32, Nos. 1/2 (1991), pp. 10-21.
Xenogeneic Transplantations, Auchincloss, Jr., Transplantation, 46(1):1-20 (1989).
Ivan M. Roitt, Jonathan Brostoff and David K. Male, "Immunology", ch. 24 Transplantation and Rejection, pp. 24.1 to 24.9, Gower Medical Publishing (1985).

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