Tissue plasminogen activator derivatives

Details Tissue plasminogen activator derivatives Tissue plasminogen activator derivatives

1995-06-06

1998-03-17

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435219, 424 9463, 424 6464, C12N 964, C12N 1555, A61K 3849

Patent

active

057285667

ABSTRACT:
Tissue plasminogen activator (t-PA) derivatives are produced in useful quantifies using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid substitution derivatives. A deletion derivative lacking the N-terminal first 68 amino acids is specifically exemplified having requisite t-PA characteristics. The invention disclosed thus enables the production of t-PA derivatives via recombinant means. Methods, expression vehicles and various host cells useful in the production of said t-PA derivatives are also disclosed.

REFERENCES:
patent: 3904480 (1975-09-01), Hull et al.
patent: 3998947 (1976-12-01), D'Hinterland et al.
patent: 4245051 (1981-01-01), Reich et al.
patent: 4259447 (1981-03-01), Hafeli
patent: 4314994 (1982-02-01), d'Hinterland et al.
patent: 4317882 (1982-03-01), Horiguchi et al.
patent: 4370417 (1983-01-01), Hung et al.
patent: 4505893 (1985-03-01), Muri et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 4853330 (1989-08-01), Goeddel et al.
patent: 5185259 (1993-02-01), Goeddel et al.
Camiolo et al., (1971) PSEBM, 138:277.
Thorsen et al., (1972), Thrombos. Daethes. haemorrh. 28:65.
Granelli-Piperno et al., (1978). J. Exp. Med. 148:223.
Thorsen (1977). Danish Med. Bulletin. 24-189.
Allen, Cell Biol. Int. Rep., 4(9), 803 (1980) Chemical Abstracts, vol. 93, 183281e, p. 396 (1980).
Angles-Cano et al., C.R. Acad. Sc. Paris, 289, p. 485 (1979) Chemical Abstracts, vol. 92, 36746m (1980).
Aoki, J. Biochem 75, p. 731 (1974).
Hoylaerts et al., J.B.C. 257, No. 6, 2912-2919 (1982).
Weimar et al., The Lancet 2, 1018-1020 (Nov. 7, 1981).
Wiman et al., Nature 272, No. 5648, 549-550 (Mar. 2, 1978).
Ny et al. (1984), Proc. Natl. Acad. Sci., USA, 81:5355.
Kingsman et al, Genetic Engineering, Blackwell Scientific Publications, pp. 110-121 (1988).
Wallen (1978), Progress in Chem. Fibrinolysis and Thrombolysis, 3:167.
Wilson et al., (1980), Chem. Ab., 92, No. 144679a.
Collen (1980), Edward Kowalski Memorial Lecture Thromb. Haem., 43:77.
Wun et al., (1982), Jrnl. Biol. Chem., 257:3276.
Rijken et al., (1980), Thromb. Res., 18:815.
Wigler et al., (1980), Proc. Natl. Acad. Sci. USA, 77:3567.
Kaufman et al., (1982), J. Mol. Biol., 159:601.
Kaufman et al., (1982). Gene Applification, pp. 245-250.
Weissmann, et al., (1982), Phil. Trans. R. Soc. Lond.299-7.
The Newswatch, (1982) McGraw-Hill's Biotech, Newswatch2:1.
Kaufman et al., (1982), Molecul. Cell. Biol., 2:1304.
Rougeon et al., (1975), Nucl. Acids Res., 2:2365.
Rabbitts (1976). Nature, 260:221.
Maniatis et al., (1976), Cell 8:163.
O'Malley et al., (1976). ICN-UCLA Symposium, 5:309.
Salser et al., (1976), Prog. Nucl. Acids Res. Mol. Biol., 19:177.
Higuchi et al., (1976) Proc. Nat. Acad. Sci. USA. 73:3146.
McReynolds et al., (1977), J. Biol. Chem., 252-1840.
Rougeon et al., (1977). Gene 1:229.
Monahan et al., (1977), J. Biol. Chem. 252-4722.
Liu et al., (1977), Science, 196:192.
Humphries et al., (1977), Nucl. Acids Res. 4:2389.
Ullrich et al., (1977), Science, 196:313.
McReynolds et al., (1977) Gene,2:217.
Seeburg et al., (1971), Nature, 270:486.
Shine et al., (1977), Nature, 270-494.
Seidman et al., (1978), Nature, 271:582.
Wilson et al., (1978), Nucl. Acids Res., 5:563.
Little et al., (1978), Nature, 273:640.
Cummings et al., (1978), Nature, 276:418.
Harpold et al., (1978),Nucl. Acids Res., 5:2039.
Sim et al., (1978), Cold Spring Harbor Symp. Quant. Biol. 42:933.
Villa-Komaroff, (1978) Proc. Nat. Acad. Sci. USA, 75:3727.
Gordon et al., (1978), J. Biol. Chem., 253:8629.
Wall et al., (1978). Nucl. Acids Res., 5:3113.
Sippel et al., (1978), Nucl. Acids Res., 5:3275.
Wahli et al., (1978), Dev. Biol. 67:371.
Lehrach et al., (1978), Proc. Nat. Acad. Sci. USA, 75:5417.
Schibler et al., (1978), Cell , 15:1495.
Sobel et al., (1978), Proc. Nat. Acad. Sci. USA, 75:5846.
Chang et al., (1978), Nature, 275:617.
Poon et al., (1978), Nucl. Acids Res., 5:4625.
Nakanishi et al., (1978), Proc. Nat. Acad. Sci. USA, 75:6021.
Yamamoto et al., (1980), J. Biol. Chem. 255-2612.
Early et al., (1979), Proc. Nat. Acad. Sci. USA, 76:857.
Innis et al., (1979), Arch. Biochem. Biophys., 195:128.
Gubbins et al., (1979), Nucl. Acids Res., 6:915.
King et al., (1979), J. Biol. Chem., 254:6781.
Roberts et al., (1979), Proc. Nat. Acad. Sci. USA, 76:2153.
Lehrach et al., (1979), Biochemistry, 18:3146.
Rogers et al., (1979), Nucl. Acids Res., 6:3305.
Tilgham et al., (1979), J. Biol. Chem. 254:7393.
Cochet et al., (1979), Nucl. Acids Res., 6:2435.
Buell et al., (1979), J. Biol. Chem., 254:9277.
Wahl et al., (1979), J. Biol. Chem. 254:8679.
Sargent et al., (1979), Proc. Natl. Acad. Sci., USA, 76:3256.
Bhat et al., (1979), Proc. Nat. Acad. Sci. USA, 76:3299.
Eantoni et al., (1979), Nucl. Acids. Res. 6:3505.
Martial et al., (1979), Science 205:602.
Kioussis et al., (1979). Proc. Nat. Acad. Sci., 76:4370.
Ohno et al., (1980), Biochem. Biophys. Acta., 606:34.
Fiddes et al., (1979), Nature, 281:351.
Goeddel et al., (1979), Nature, 281:544.
Kronenberg et al. (1979), Proc. Nat. Acad. Sci., 76:4981.
Roskam et al., (1979), Nucl. Acids Res., 7:305.
Liebscher et al., (1980), Gene, 9:233.
Chan et al., (1979), Proc. Nat. Acad. Sci. USA, 76:5036.
Bell et al., (1979), Nature, 282:525.
Sim et al., (1979), Cell, 18:1303.
Tucker et al., (1979), Science, 206:1299.
Richards et al., (1979) Nucl. Acids Res. 7:1137.
Gough et al., (1980), Proc. Nat. Acad Sci. USA, 77:554.
Firtel et al., (1979), Proc. Nat. Acad. Sci. USA, 76:6206.
Adams et al., (1980), Biochemistry, 19:2711.
Gough et al., (1980), Biochemistry, 19:2702.
Obata et al., (1980), Gene 9:87.
Katcoff et al., (1980), Proc. Nat. Acad. Sci.USA, 77-960.
Joho et al., (1980), Proc. Nat. Acad. Sci. USA, 77:1106.
Wieringa et al., Nucl. Acids Res. 7:2147.
Merlino et al., (1980), Proc. Nat. Acad Sci. USA, 77:765.
Calame et al., (1980), Nature, 284:452.
Taniguchi et al., (1979), Proc. Japan Acad. 55:464.
Hoeijmakers et al., (1980), Gene 8:391.
Law et al., (1980), Gene, 10:53.
Meyuhas et al., (1980), Gene, 10:113.
Griffin-Shea et al. (1980), Cell, 19:915.
Cleveland et al., (1980), Cell 20:95.
Matthyssens et al., (1980), Nucl. Acids Res. 8:703.
Nagata et al., (1980), Nature, 284:316.
Cooke et al., (1981), J. Biol. Chem., 256:4007.
Cooke et al., (1980), J. Biol. Chem., 255:6502.
Dunnick et al., (1980), Nucl. Acids Res., 8:1475.
Vamvakopoulos et al., (1980), Proc. Nat. Acad. Sci USA, 77:3149.
Auffray et al., (1980), Nucl. Acids Res., 8:1231.
Deacon et al., (1980), Nucl. Acids Res. 8:1187.
Norgard et al., (1980), J. Biol. Chem. 255:7665.
Nilson et al., (1980), Nucl. Acids Res., 8:1561.
Tsitilou et al., (1980), Nucl. Acids Res., 8:1987.
Gorecki et al., (1980), Proc. Nat. Acad. Sci USA, 77:3686.
Hobart et al., (1980), Nature, 288:137.
Sures et al., (1980), Science, 208:57.
Derynck et al., (1980), Nature 285:542.
Fiddes et al., (1980), Nature, 286:684.
Richards et al., (1980), J. Biol. Chem., 255:9306.
Schwartz et al., (1980), Biochem., 19:5883.
Schibler et al., (1980), J. Mol. Biol. 142:93.
Liao et al., (1980), J. Biol. Chem., 255:8046.
Taniguchi et al., (1980), Proc. Nat. Acad. Sci. USA 77:4003.
Ordahl et al., (1980), Proc. Nat. Acad. Sci. USA 77:4519.
Amara et al., (1980), Proc. Nat. Acad. Sci. USA, 77:4444.
Miller et al., (1980), J. Biol. Chem. 255-7521.
Chandra et al., (1980), Biochem. Biophys. Res. Commun. 95:197.
Christophe et al., (1980), Eur. J. Biochem 111:419.
Zakut et al., (1980), Nucl. Acids Res., 8:3591.
Hobart et al., (1980), Science, 210:1360.
MacGillivray et al., (1980), Proc. Nat. Acad. Sci. USA, 77:5153.
Ginsburg et al., (1980), Nucl. Acids Res., 8:3553.
Cozens et al., (1980), Eur. J. Biochem., 112:443.
Goeddel et al., (1980), Nature, 287:411.
Medford et al., (1980), Proc. Nat. Acad. Sci. USA, 77:5749.
Dolby et al., (1980), Proc. Nat. Acad. Sci. USA, 77:6027.
MacDonald et al., (1980), Nature, 287:117.
Fagan et al., (1981), J. Biol. Chem., 256:520.
Streuli et al., (1980), Science, 209:1343.
Richards et al., (1981), J. Biol. Chem., 256:526.
Odink et al., (1981), J. Biol. Chem., 256:1453.
Bedbrook et al., (1980), Nature, 287:692.
Miller et al., (1980), Endocrinology, 107:851.
Goodman et al.

Affiliated with

Also associated with

Rating

Tissue plasminogen activator derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue plasminogen activator derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue plasminogen activator derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-956775