Polymerase delta mutations in colorectal tumors with replication

Details Polymerase delta mutations in colorectal tumors with replication Polymerase delta mutations in colorectal tumors with replication

1994-12-30

1998-03-17

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

057285233

ABSTRACT:
The human pol .delta. gene, responsible for a replication error phenotype in some colorectal tumors, can be used for diagnostic and therapeutic purposes. It can be used to demonstrate the existence of germline or somatic mutations in replication error (RER.sup.+) tumor cells.

REFERENCES:
Yang et al. "Molecular Cloning of the cDNA for the catalytic subunit of human polymerase delta" Nucleic Acids Research 20(4) 735-745, 1992.
Strand et al. "Destabilization of tracts of simple repetitive DNA in yeast y mutations affecting DNA mismatch repair" Nature 365: 274-276, 1993.
Da Costa et al "polymerase delta variants in RER colorectal tumours" Nature Genetics 9: 10-11, 1995.
Yang et al., "Molecular Cloning of the cDNA for the Catalytic Subunit of human DNA Polymerase .delta.", Nucleic Acids Research, 20(4):735-745 (1992).
Chung et al., "Primary Structure of the Catalytic Subunit of Human DNA Polymerase .delta. and Chromosomal Location of the Gene", Proc. Natl. Acad. Sci. USA 88:11197-11201 (1991).
Strand et al., "Destabilization of Tracts of Simple Repetitive DNA in Yeast by Mutations Affecting DNA Mismatch Repair", Nature 365:274-276 (1993).
DaCosta et al., "Polymerase Delta Variants in RER Colorectal Tumors", Nature Genetics 9(1):10-11 (1995).

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