Genetically engineered immunoglobulins with specificity for glyc

Details Genetically engineered immunoglobulins with specificity for glyc Genetically engineered immunoglobulins with specificity for glyc

1996-06-27

1999-06-01

Caputa, Anthony C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

53038825, 4241331, C07H 2104, C07H 1600, A61K 39395

Patent

active

059089253

ABSTRACT:
This invention deals with genetically engineered immunoglobulins with affinity and specificity for (human) glycated albumin. The invention is directed to the DNA which encodes the immunoglobulins. The DNA sequence can be manipulated to produce chimeras and fragments such as Fab, F(ab').sub.2 or ScFv. The immunoglobulins can be produced by recombinant DNA methods and readily purified. The invention also provides a novel and improved method for treating the complications of diabetes.

REFERENCES:
patent: 5091513 (1992-02-01), Huston et al.
patent: 5223392 (1993-06-01), Cohen
patent: 5518720 (1996-05-01), Cohen
patent: 5530101 (1996-06-01), Queen et al.
Cohen et al (J. Clin. Inv. vol. 95 pp. 2338-2345), May 1995.
Dixon Advances in Immunology Academic Press vol. 44 pp. 65-92, 1989.

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