Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1997-04-23
1999-06-01
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
4352528, 435849, C12P 1314, C12N 120
Patent
active
059087684
ABSTRACT:
A fermentative process for producing L-glutamic acid efficiently and at low cost is disclosed. Also disclosed are microorganisms having improved ability to produce L-glutamic acid. These microorganisms belong to the genus Escherichia, have resistance to an aspartic acid antimetabolite, and are deficient in .alpha.-ketoglutaric acid dehydrogenase activity. The process comprises cultivating one of these microorganisms in a liquid medium, accumulating L-glutamic acid in the culture medium, and collecting L-glutamic acid. In particular, E. coli AF13199 (FERM BP-5807).
REFERENCES:
patent: 2947666 (1960-08-01), Huang
patent: 5573945 (1996-11-01), Ono et al.
Spring et al., "L-Asparaginase Genes in Escherichia coli: Isolation of Mutants and Characterization of the ansA Gene and its Protein Product", Journal of Bacteriology, Apr. 1986, pp. 135-142.
Reitzer L.J., "Aspartate and Asparagine Biosynthesis", In: "Amino Acids: Biosynthesis and Genetic Regulation", Edited by Herrmann K.M. and Somerville R.L., Addison-Wesley Publishing Company, 1983, pp. 133-145.
Izui Hiroshi
Matsui Kazuhiko
Ono Eiji
Tsujimoto Nobuharu
Afremova Vera
Ajinomoto Co. Inc.
Saucier Sandra E.
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