Protein inhibitor of neuronal nitric oxide synthase

Details Protein inhibitor of neuronal nitric oxide synthase Protein inhibitor of neuronal nitric oxide synthase

1996-08-30

1999-06-01

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 771, 435 772, 435 691, 435 692, 435 697, 435 698, 435 699, 435 914, 435 9141, 435174, 435183, 4351721, 4351722, 530350, 536 231, 536 234, 536 235, 2041828, G01N 3353, C07K 1400, C07H 2104

Patent

active

059087560

ABSTRACT:
An nNOS associated protein designated PIN-1 (Protein Inhibitor of nNOS) has been identified. It physically interacts with nNOS and inhibits its activity. Multiple lines of evidence indicate that PIN-1 is a regulator of nNOS: it is physiologically associated with nNOS, and it inhibits its catalytic activity. The extraordinary evolutionary conservation of PIN-1 and preliminary evidence that it interacts with multiple proteins, suggests that it may be a major biological regulatory protein influencing numerous physiological processes.

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