Antipsychotic 4-(naphthalenyloxy)piperidine derivatives

Details Antipsychotic 4-(naphthalenyloxy)piperidine derivatives Antipsychotic 4-(naphthalenyloxy)piperidine derivatives

1982-09-24

1984-04-17

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546206, A61K 31445, C07D21144

Patent

active

044434626

ABSTRACT:
Novel compounds of the formula ##STR1## wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R.sub.1 is hydrogen, alkyl, alkoxy or halogen, and Z is carbonyl or hydroxymethylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula ##STR2## or their salts wherein R has the meanings defined above and R.sub.2 is hydrogen, lower alkyl or phenyl(lower alkyl).

REFERENCES:
patent: 3743645 (1973-07-01), Helsley
patent: 3795677 (1974-03-01), Carr et al.
patent: 4145427 (1979-03-01), Langbein et al.
patent: 4160837 (1979-07-01), Paioni
patent: 4246268 (1981-01-01), Carr
Janssen, P., et al., Arz. Forsch., 15, 105 (1965).
Carlsson, A., Am. J. Psychiatry 135(2), 164-173 (1978).

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