Use of the protease domain of human plasminogen activator for th

Details Use of the protease domain of human plasminogen activator for th Use of the protease domain of human plasminogen activator for th

1998-01-20

1999-06-01

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

423 9464, 435216, 435217, 435219, 435212, A61K 3843

Patent

active

059086254

ABSTRACT:
The invention relates to the use of thromboembolic proteins. These contain, as their only structural portion effecting thrombolytic activity, the protease domain of human tissue type plasminogen activator. These derivatives show reduced side effects, such as a reduction in bleeding while demonstrating remarkable in vivo efficacy. The effect is surprising, given their in vitro properties.

REFERENCES:
patent: 5223256 (1993-06-01), Stern et al.
Burck et al., "Characterization of a Modified Human Tissue Plasminogen Activator Comprising a Kringe-2 and a Protease Domain", J. Biol. Chem 265(9): 5170-5177 (1990).
Robinson et al., "Redesigning t-PA for improved thrombolytic therapy", Trends Biotech. 9(3): 86-90 (1991).
Gething et la., "Variants of Human Tissue Type Plasminogen Activator That Lack Specific Structural Domains of the Heavy Chain", EMBO J 7(9): 2731-2740 (1988).

Affiliated with

Also associated with

Rating

Use of the protease domain of human plasminogen activator for th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of the protease domain of human plasminogen activator for th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of the protease domain of human plasminogen activator for th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-953539