Stable microbubble suspensions comprising saturated phospholipio

Details Stable microbubble suspensions comprising saturated phospholipio Stable microbubble suspensions comprising saturated phospholipio

1997-06-26

1999-06-01

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

424 952, 424450, 514 78, 514121, A61B 813

Patent

active

059086106

ABSTRACT:
Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

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