Aminocrotonyl 3,5-dinitropyridine useful as adjuncts to radiatio

Details Aminocrotonyl 3,5-dinitropyridine useful as adjuncts to radiatio Aminocrotonyl 3,5-dinitropyridine useful as adjuncts to radiatio

1982-07-19

1984-04-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546307, C07D21361, A61K 3144

Patent

active

044434588

ABSTRACT:
Aminocrotonyl derivatives of 3,5-dinitropyridines are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
Ainsworth et al., Can. J. Biochem., 10156, pp. 457-461, (1978).
Adams et al., Lancet, pp. 186-188, Jan. (1976).
Olive, P. L., Cancer Res., 39, pp. 4512-4515, Nov. (1979).
Anderson, R. F. et al., "Radiosensitization . . . by Nitropyridium Compounds", Br. J. Cancer, 37, Suppl. III, pp. 103-106, (1978).
Rauth et al., "In Vitro testing-Radiosensitizers", Chem. Abst., 85:40894F, (1976).
Denekamp et al., "Hypoxic Cells Radiosensitizers", Chem. Abst., 82:93112w.
Chin et al., "Screening-Radiosensitizers", Chem. Abst., 89:20966z.

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