Process for the production of 2-imidazolones

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C07D23330

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053388623

ABSTRACT:
The present invention pertains to a process for producing a 2-imidazolone from a ureidoacetal. The ureidoacetal is subjected to an acid catalyzed condensation in order to produce the 2-imidazolone. The reaction is conducted in an alcoholic solvent in order to minimize the production of a polymeric by-product.

REFERENCES:
O. Wong, et al., Heterocycles, 26(12), 3153-3158 (1987).
R. Duschinsky et al., Journal of the American Chemical Society, vol. 64, pp. 2350-2355 (1946).
Hoffman, Imidazole and Its Derivatives, Part I, Chapter III, p. 65, Interscience, New York (1953).
N. Leonard et al., Journal of the American Chemical Socieity, vol. 98, pp. 8218-8221 (1976).
W. Marckwald, Berichte Deutschen Chem. Ges. 25:2354-2373, 1892.

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