Substituted 2-imidazolone derivatives, their preparation and pha

Details Substituted 2-imidazolone derivatives, their preparation and pha Substituted 2-imidazolone derivatives, their preparation and pha

1993-05-10

1994-08-16

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514392, 548112, 548252, 5483235, A61K 31415, C07D25704, C07D23332, C07F 906

Patent

active

053387520

ABSTRACT:
##STR1## Substituted 4,5-diaryl-2-imidazolones of structure (I), in which each group AR is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R.sup.1 is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; n is 4 to 12; and X is 5-tetrazolyl, SO.sub.3 H, P(O)(OR).sub.2, P(O)(OH).sub.2 or P(O)(R)(OR) in which R is hydrogen acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders.

REFERENCES:
CA 116(25):255613h Preparation of . . . Agonists, Hickey et al., p. 792, 1992.

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