Method of preparing high titer anti-respiratory syncytial virus

Details Method of preparing high titer anti-respiratory syncytial virus Method of preparing high titer anti-respiratory syncytial virus

1987-03-09

1988-01-05

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 85, 424 86, 424 89, 530388, 530389, 530390, A61K 3942, A61K 3925

Patent

active

047177667

ABSTRACT:
Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to respiratory syncytial virus (e.g. minimum ELISA titer of at least 1:110,000). Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with respiratory syncytial virus infection or at risk of such infection, may receive the present product to raise serum antibody titers to respiratory syncytial virus. Resultant product has an ELISA anti-RSV titer of at least about 1:250,000.

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Chem. Abstracts, vol. 89, 74058j, (1978), Richardson et al.
Infect. Immun., 20(3): 660-664, (1978), Richardson et al.
J. Infectious Diseases, 152, 1033, (1985), Hemming et al.

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