Monoclonal antibody and method for preparation of hybridoma prod

Details Monoclonal antibody and method for preparation of hybridoma prod Monoclonal antibody and method for preparation of hybridoma prod

1988-06-03

1990-07-17

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 530387, 935104, C12P 2100, C12N 1500, C12N 500

Patent

active

049421310

ABSTRACT:
Disclosed are a monoclonal antibody which recognizes specifically an O-acylsialic acid containing sugar chain and a method for preparing a hybridoma capable of producing the monoclonal antibody, which comprises using an autoimmune disease animal as the immunization animal and/or using a substance containing said sugar chain adsorbed on Salmonella minesota bacteria as the immunogen.
The monoclonal antibody of the present invention capable of recognizing the above described sugar chain which may be considered to be antigens related with human cancer are very useful in diagnosis of cancer.

REFERENCES:
Higashi, H, et al. Biochem, Biophys. Res. Comm. vol. 79, pp. 388-395, 1977.
Higashi, H., et al. Cancer Research, 45, pp. 3796-3802, 1985.
Miyoshi, et al., Mol. Immunol. 23, pp. 631-638, 1986.
Kaizu, et al. J. Bio. Chem. 261, pp. 11254-11258, 1986.
In: Basic & Clinical Immunology Editors: Stiles, D. P., et al, Lange Medical Publishers, Los Altos, CA., 1984 Chap. 12 pp. 152 by Theofilopoulos, A. N.
Male, et al In: Autoimmunity: Experimental & Clinical Aspects, Editors: R. S. Schwartz & N. R. Rose vol. 475 Annals of the N.Y. Acad. Sci, p. 94, 1986.
D. A. Cheresh et al., "A Monoclonal Antiody Recognizes an O-Acylated Sialic Acid in a Human Melanoma-Associated Ganglioside"J. Biol. Chem. 259: 7453-7459 (1984).
I. Miyoshi et al., "Detection of 4-O-Acetyl-N-glycolylneuraminyl lactosylceramide as One of Tumor Associated Antigens in Human Colon Cancer Tissues by Specific Antibody", Molec. Immun. 23: 631-638 (1986).

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