Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-08-03
2000-09-12
Mertz, Prema
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 435 711, 435 712, 435471, 435325, 4352523, 4353201, 536 231, 536 235, 536 243, 536 2431, 530351, C12N 510, C12N 1519, C12N 1563, C07K 1452
Patent
active
061176540
ABSTRACT:
Novel Tango-77 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Tango-77 proteins, the invention further provides isolated Tango-77 fusion proteins, antigenic peptides and anti-Tango-77 antibodies. The invention also provides Tango-77 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Tango-77 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
REFERENCES:
Cunningham et al. (1989) Science vol. 244, pp. 1081-1085.
Rieger et al. (1976) Colonary of Genetics & Cytogenetics. Fourth Edition, pp. 16-19, Springer-Verlag.
George et al. (1988) Macromolecular Sequencing & Synthesis, Ch 12, pp. 127-149, Alan R. Liss, Inc. New York.
Auron et al., "Nucleotide Sequence of Human Monocyte Interleukin 1 Precursor cDNA", PNAS USA, 81(24):7907-11 (1984).
Carter et al., "Purification, Cloning, Expression and Biological Characterization of an Interleukin-1 Receptor Antagonist Protein", Nature, 344:633-38 (1990).
Lennard et al., "Cloning and Chromosome Mapping of the Human Interleukin-1 Receptor Antagonist Gene", Cytokine, 4(2):83-89 (1992).
March et al., Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs, Nature, 315(6021):641-47 (1985).
GenBank Accession No. P01584, Auron et al., Jul. 15, 1998.
GenBank Accession No. P18510, Carter et al., Jul. 15, 1998.
Sonnenfield et al., "The Drosphila tango gene encodes a bHLH-PAS protein that is othologous to mammalian . . . " Development 124(22):4571-82, 1997.
Pan et al., "Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic . . . " Nature Genetics 2(2):103-106, 1992.
Mertz Prema
Millennium BioTherapeutics, Inc.
LandOfFree
Nucleic acid molecules encoding Tango-77-polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules encoding Tango-77-polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules encoding Tango-77-polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-94842