Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1982-07-02
1983-12-27
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435896, 536 71, C12P 1962, C12R 154, C07H 1708
Patent
active
044231482
ABSTRACT:
20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin (20-deoxo-DMOT), specified 2'-acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing 20-deoxo-DMOT and 5-O-mycaminosyltylactone by fermentation of Streptomyces fradiae ATCC 31733 are included.
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patent: 4304856 (1981-12-01), Baltz et al.
patent: 4366247 (1982-12-01), Baltz et al.
H. Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and its Structure-Activity Relationship", Chem. Pharm. Bull. 30(1), 97-110, (1982).
A. Nagel et al., "Selective Cleavage of the Mycinose Sugar from the Macrolide Antibiotic Tylosin: A Unique Glycosidic Scission", J. Org. Chem. 44 (12), 2050-2052, (1979).
A. Kinumaki et al., "Macrolide Antibiotics M-4365 Produced by Micromonospora II. Chemical Studies," J. Antibiotic 30 (6), 450-454, (1977).
Eli Lilly and Company
Harrison Nancy J.
Shapiro Lionel M.
Whale Arthur R.
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