Synthesis of vincaminic acid derivatives

Details Synthesis of vincaminic acid derivatives Synthesis of vincaminic acid derivatives

1980-06-20

1982-02-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 70, C07D46100

Patent

active

043160298

ABSTRACT:
Vincaminic acid derivatives of formula (A) ##STR1## useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the C.dbd.N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.

REFERENCES:
patent: 3755333 (1973-08-01), Szantay et al.
patent: 3987049 (1976-10-01), Plat et al.
patent: 4033969 (1977-07-01), Sevenet et al.
patent: 4117133 (1978-09-01), Bonati et al.
Montoro, et al., Chemical Abstracts, 89, 180220r (1978).
Fieser, et al., "Advanced Organic Chemistry," Reinhold Publishing Corp., New York (1961), p. 378.

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