Dioxo piperazine compounds

Details Dioxo piperazine compounds Dioxo piperazine compounds

1980-09-15

1982-02-16

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544366, 424246, 544 27, 544 26, C07D24104

Patent

active

043160247

ABSTRACT:
Certain cephalosporins having a heterocyclicthiomethyl group at the 3-position such as cefoperazone are prepared by reacting a solution of a 7-acylamidocephalosporanic acid having a free amino group as part of said acyl substituent with about an equi-molar amount of the thiolester ##STR1## wherein --S-Het is the desired conventional heterocyclicthio group which displaces the 3-acetoxy group of the starting acid and ##STR2## is the conventional acyl group which displaces a hydrogen on the free amino group which is part of the acyl substituent of the starting 7-acylamidocephalosporanic acid.

REFERENCES:
patent: 4061748 (1977-12-01), Yamara et al.
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4198504 (1980-04-01), Naito et al.
patent: 4258195 (1981-03-01), Shibuya et al.
Saikawa et al., Yakugaku Zasshi, 97,980 (1977).
Matsubara et al., Antimicrob Agents Chemother., 16, 731 (1979).
Saikawa et al., Yakugaku Zasshi 99,929 (1979).
The Peptides, vol. 1, pp. 105-108 (1965), Academic Press, NY.
Chemistry of the Amino Acids, vol. 2, 1027-1048 (1961), John Wiley & Sons, Inc.

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