Methods of inducing sedation using certain spiroalkanone-imides

Details Methods of inducing sedation using certain spiroalkanone-imides Methods of inducing sedation using certain spiroalkanone-imides

1971-04-12

1976-10-12

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, A61K 31445, A61K 3140

Patent

active

039858880

ABSTRACT:
Compounds having the general formula: ##SPC1##
Wherein R.sup.1 and R.sup.2 represent hydrogen, halogen, lower alkyl, lower alkoxy, or nitro, and wherein R.sup.1 and R.sup.2 may be the same or different. R.sup.3 may be hydrogen or lower alkyl, and X and Y may be one or two. They have been found to be useful sedative type depressants of the central nervous system.
Most of the compounds having the general formula indicated above are new but others such as 2,3-dihydrospiro[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione which has useful sedative properties have been reported in the literature.

REFERENCES:
patent: 3379731 (1968-04-01), Walker
Koelsch: J. Org. Chem. 25: pp. 164-174 (1960).
Dews: Chemical Abstracts 47: 6043 i.
Campbell: J. Chem. Soc. vol. 1954 (pp. 1377-1380).

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