Polynucleotide reagents containing modified deoxyribose moieties

Details Polynucleotide reagents containing modified deoxyribose moieties Polynucleotide reagents containing modified deoxyribose moieties

1994-08-25

1997-01-28

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 536 2432, 536 253, 536 2531, 536 2532, 435 6, C07H 2104, C07H 2100, C07H 2102, C12Q 168

Patent

active

055979092

ABSTRACT:
Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties -A-Z-(R.sup.9).sub.n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.

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