Use of a substituted 1,3-benzodioxole to reduce a wasting condit

Details Use of a substituted 1,3-benzodioxole to reduce a wasting condit Use of a substituted 1,3-benzodioxole to reduce a wasting condit

1995-06-07

1997-01-28

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514465, A61K 3142, A61K 3136

Patent

active

055978436

ABSTRACT:
The present invention provides a method of reducing a wasting condition, which can occur due to a pathology or to a particular physiologic or metabolic state in a subject, by administering to the subject a substituted 1,3-benzodioxole.

REFERENCES:
patent: 5061727 (1991-10-01), Bloom et al.
patent: 5087472 (1992-02-01), Nissen
patent: 5106867 (1992-04-01), Bloom et al.
patent: 5151439 (1992-09-01), Bloom et al.
patent: 5348979 (1994-09-01), Nissen et al.
Bloom, Jonathan D. et al., "Disodium (R,R)-5-[[2-(3-Chlorophenyl)-2-hydroxyethyl]-amino]propyl-1,3-benzodioxole -2,2-dicarboxylate (CL316,243). A Potent .beta.-Adrenergic Agonist Virtually Specific for .beta..sub.3 Receptors." J. Med. Chem. 35:3081-3084 (1992).
Kim, Yong S. and Sainz, Roberto D. ".beta.-Adrenergic Agonists and Hypertrophy of Skeletal Muscles." Life Sci. 50:397-407 (1992).
Frishman, William H. "Pindolol: A New .beta.-Adrenoceptor Antagonish with Partial Agonist Activity." New England J. Med. 308:940-944 (1983).
Arch, J. R. S. "The Brown Adipocyte .beta.-Adrenoceptor." Proceedings Nutri. Soc. 48:215-223 (1989).
Arch, J. R. S. et al., "Atypcial .beta.-adrenoceptor on Brown Adipocytes as Target for Anti-Obesity Drugs." Nature 309:163-165 (1984).
Tan, Suon and Curtis-Prior, P. B. "Characterization of the Beta-Adrenoceptor of the Adipose Cell of the Rat." Inter. J. Obesity 7:409-414 (1983).
Bond, Richard A. and Clarke, David E. "Agonist and Antagonist Characterization of a Putative Adrenoceptor with Distinct Pharmacological Properties from the .alpha.-and .beta.-subtypes." Br. J. Pharmacol. 95:723-734 (1988).
Bond, Richard A. and Clarke, David E. "A Response to Isoprenaline Unrelated to .alpha.-and .beta.-Adrenoceptor Agonism." Br. J. Pharmac. 91:683-686 (1987).
Arch, Jonathan R. S. "Thermogenic and Antiobesity Activity of a Novel .beta.-Adrenoceptor Agonist (BRL 26830A) in Mice and Rats." Amer. J. Clin. Nutri. 38:549-558 (1983).
F eve, Bruno et al., "Differential Regulation of .beta..sub.1 -and .beta..sub.2 -Adrenergic Receptor Protein and mRNA Levels by Glucocorticoids during 3T3-f442A Adipose." J. Biol. Chem. 265:16343-16349 (1990).
Marullo, Stefano et al., "Selective Binding of Ligands to .beta.1, .beta.2 or Chimeric .beta.1/.beta.2-Adrenergic Receptors Involves Multiple Subsites." EMBO. J. 9:1471-1476 (1990).
Tate, Keri M. et al., "Expression of Three Human .beta.-adrenergic-receptor Subtypes in Transfected Chinese Hamster Ovary Cells." Eur. J. Biochem. 196:357-361 (1991).
Emorine, Laurent J. et al., "Molecular Characterization of the Human .beta..sub.3 -Adrenergic Receptor." Science 245:1118-1121 (1989).
Emorine, Laurent J. et al., "Structural Basis for Functional Diversity of .beta..sub.1 -, .beta..sub.2 -and .beta..sub.3 -Adrenergic Receptors." Biochem. Pharmacol. 41:853-859 (1991).
Challiss, R. A. John et al., "An Investigation of the .beta.-Adrenoceptor that Mediates Metabolic Responses to the Novel Agonist BRL28410 in Rat Soleus Muscle." Biochem. Pharmacol. 37:947-950 (1988).

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