Treatment of optic neuritis

Details Treatment of optic neuritis Treatment of optic neuritis

1994-06-23

1997-01-28

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514145, 514148, 5142248, 5142312, 5142332, 514256, 514260, 514277, 514278, 514299, 514312, 514314, 514317, 514345, 514469, 514492, 514493, 514498, 514501, 514504, 514530, 514601, 514602, 514608, 514613, 514616, 514646, 514647, A01N 4304

Patent

active

055978096

ABSTRACT:
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.

REFERENCES:
Levy et al, Neuralogy, vol. 40, #5, pp. 852-855, 1990.
Chemical Abstracts, vol. 119, #3 p. 75, 1993, 203a8.
Fraunfelder et al., Journal of Toxicology 13:311-316, 1994.
Pellegrini et al., Annals of Neurology 33:403-407, 1993.
Campbell, I. A., et al., "Ethambutol and the Eye", 1988, Letter: The Lancet, 2(8601):113-14.
Choi, D. W., et al., "Glutamate Neurotoxicity, Calcium, and Zinc.sup..alpha. ", 1989, Annals NY Acad. Sci., 568:219-24.
Christine, C. W., et al., "Effect of Zinc on NMDA Receptor-Mediated Channel Current in Cortical Neurons", 1990, J. Neuroscience, 10(1):108-16.
Dreyer, E. B., et al., "Greater Sensitivity of Larger Retinal Ganglion Cells to NMDA-mediated Cell Death", 1994, Neuroreport, 5(5):629-31.
Dreyer, E. B., et al., "HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists", 1990, Science, 248:364-67.
Elo, R., et al., "Serum Iron, Copper, Magnesium and Zinc Concentration in Chronic Pulmonary Tuberculosis during Chemotherapy with Capreomycin-Ethambutol-Rifampicin Combinations", 1970, Scand. J. Resp. Dis., 51:249-55.
Figueroa, R., et al., "Effect of Ethambutol on the Ocular Zinc Concentration in Dogs", 1971, Am. Rev. of Respiratory Disease, 104(4):592-94.
Hahn, J. S., et al., "Central Mammalian Neurons Normally Resistant to Glutamate Toxicity are Made Sensitive by Elevated Extracellular Ca.sup.2+ : Toxicity is Blocked by the N-methyl-D-aspartate Antagonist MK-801", 1988, Proc. Natl. Acad. Sci. USA, 85:6556-60.
Joubert, P. H., et al., "Subclinical Impairment of Colour Vision in Patients Receiving Ethambutol", 1986, Br. J. Clin. Pharmac., 21:213-16.
Kahana, L. M., "Ethambutol and the Eye", 1988, Letters: The Lancet, p. 627.
Kakisu, Y., et al., "Pattern Electroetinogram and Visual Evoked Cortical Potential in Ethambutol Optic Neuropathy", 1988, Documenta Ophthalmologica, 67:327-34.
Levy, D. I., et al., "Comparison of Delayed Administration of Competitive and Uncompetitive Antagonists in Preventing NMDA Receptor-mediated Neuronal Death", 1990, Neurology, 40(5):852-55.
Levy, D. I., et al., "Redox Modulation of NMDA Receptor-mediated Toxicity in Mammalian Central Neurons", 1990, Neuroscience Letters, 110:291-96.
Lipton, S. A., et al., "Mechanisms of Disease", 1994, N. Eng. J. Med., 330(9):613-22.
Lucas, D. R., et al., "The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina", 1957, AMA Archives, Ophthalmology, 58(1):193-201.
Olney, J. W., "Glutamate-Induced Retinal Degeneration in Neonatal Mice. Electron Microscopy of the Acutely Evolving Lesion", 1969, J. Neuropathology and Experimental Neurology, 28:455-74.
Petrera, J. E., et al., "Serial Pattern Evoked Potential Recording in a Case of Toxic Optic Neuropathy Due to Ethambutol", 1988, Electroencephalography and Clin. Neurophysiology, 71:146-49.
Sucher, N. J., et al., "N-methyl-D-aspartate Antagonists Prevent Kainate Neurotoxicity in Rat Retinal Ganglion Cells In Vitro", 1991, J. Neuroscience, 11(4):966-71.
Sucher, N. J., et al., "Calcium Channel Antagonists Attenuate NMDA Receptor-mediated Neruotoxicity of Retinal Ganglion Cells in Culture", 1991, Brain Research, 551:297-302.
Weiss, J. H., et al., "The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity", 1990, Science, 247:1474-77.
Yeh, G., et al., "Evidence that Zinc Inhibits N-Methyl-D-Aspartate Receptor-Gated Ion Channel Activation by Noncompetitive Antagonism of Glycine Binding", 1990, Molecular Pharmacology, 38(1):14-19.

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