Transdermal insulin

Details Transdermal insulin Transdermal insulin

1994-09-07

1997-01-28

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424449, 530303, 604 20, A61K 3828, A61N 130, C07K 1462

Patent

active

055977960

ABSTRACT:
Insulin analogues have been developed which are well suited for transdermal administration by iontophoresis. The insulin analogues have a negative charge at neutral pH and a reduced tendency to association. They are prepared by altering the human insulin molecule by substituting at least two of the amino acid residues of human insulin by Glu and/or Asp at selected positions in the molecule.

REFERENCES:
patent: 5149777 (1992-09-01), Hansen et al.
patent: 5514646 (1996-05-01), Chance et al.
Library of Congress Data-base from "Internet".
Diabetes Care, vol. 13, No. 9, issued Sep. 1990, Brange et al, "Monomeric Insulins . . . ", pp. 923-954.
Diabetes, vol. 21, issued 1972, Smith, "Amino Acid Sequences of Insulins", pp. 457-460.
Siddiqui et al, "Facilitated Transdermal Transport of Insulin," J. Pharm. Sci. 76(4), Apr. 1987. pp. 341-345.
Zimmerman et al, "Guinea Pig Insulin", J. Biol. Chem. 249(13), Jul. 10, 1974. pp. 4021-4025.

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