Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-01-27
1997-01-28
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4352523, 4353201, 536 2351, 536 231, C07K 1461, C12N 1563, C12P 2106, C07H 2102
Patent
active
055977090
ABSTRACT:
There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
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Adams Mark D.
Coleman Timothy A.
Gocayne Jeannine D.
Rosen Craig A.
Draper Garnette D.
Herron Charles
Human Genome Sciences Inc.
Kemmerer Elizabeth C.
Olstein Elliot M.
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