Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1989-12-08
1991-05-07
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
562465, 562469, 562471, 562472, C07C 5102
Patent
active
050138642
ABSTRACT:
A process for producing an .alpha.-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give an alkoxide followed by removal of the organic solvent and reaction of the alkoxide with a salt of a monohaloacetic acid in a polar aprotic solvent such as DMSO to give the corresponding alkoxyacetate salt which then may be recovered or may optionally be converted to the corresponding acid by contacting the alkoxy acetate salt with an acid.
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Fuson et al., Organic Synthesis Collected Volumes, 2: 260-262 (1943).
Campbell Arthur L.
Mueller Richard A.
Ng John S.
Partis Richard A.
Clarke Vera C.
Dees Jos,e G.
G. D. Searle & Co.
Kanady Mary Jo
Matukaitis Paul D.
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