Process for preparation of .alpha.-alkoxy acetic acids and their

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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562465, 562469, 562471, 562472, C07C 5102

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active

050138642

ABSTRACT:
A process for producing an .alpha.-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give an alkoxide followed by removal of the organic solvent and reaction of the alkoxide with a salt of a monohaloacetic acid in a polar aprotic solvent such as DMSO to give the corresponding alkoxyacetate salt which then may be recovered or may optionally be converted to the corresponding acid by contacting the alkoxy acetate salt with an acid.

REFERENCES:
patent: 3255241 (1966-06-01), Schultz et al.
patent: 3918899 (1975-11-01), Perrier et al.
patent: 4711903 (1987-12-01), Mueller et al.
patent: 4755524 (1988-07-01), Mueller et al.
patent: 4804777 (1989-02-01), Summer et al.
Fuson et al., Organic Synthesis Collected Volumes, 2: 260-262 (1943).

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