Process for producing di-tert-butyl dicarbonate

Details Process for producing di-tert-butyl dicarbonate Process for producing di-tert-butyl dicarbonate

1998-11-04

2000-02-01

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbonate esters

C07C 6806, C07C 6804

Patent

active

060205148

ABSTRACT:
A process for producing di-tert-butyl dicarbonate by continuously carrying out the following steps of reacting tert-butyl alcohol with sodium to form sodium tert-butoxide, reacting the sodium tert-butoxide with carbon dioxide to form mono-tert-butyl sodium carbonate, and reacting the mono-tert-butyl sodium carbonate with an aromatic sulfonyl halide such as p-toluenesulfonyl chloride in the presence of a tertiary amine such as N,N,N',N'-tetramethylethylenediamine, without isolating an intermediate in the middle of each reaction stage. This process is an industrially advantageous process for producing di-tert-butyl dicarbonate from tert-butyl alcohol and an alkali metal.

REFERENCES:
patent: 5151542 (1992-09-01), Kurimoto et al.
patent: 5750758 (1998-05-01), Zambounis et al.
Database WPI, Week 9351, Derwent Publications Ltd., London, GB; JP 05 310648 A (Tokuyama Soda KK), Nov. 22, 1993.
Joseph H. Howe et al: "An Improved Synthesis of Dicarbonates: Di-t-butyl Dicarbonate" Journal of Organic Chemistry, vol. 27, No. 5, May 11, 1962, pp 1901-1902.
Borovicka, Milos et al. Czechoslovak Patent CS 247846, Jan. 15, 1987; STN.RTM. CAPlus database, Accession No. 1988:408418, 1988.
Miyazaki, Kojiro et al. Japan Kokai Tokkyo Koho JP 04-103,562, Apr. 6, 1992; STN.RTM. CAPlus database, Accession No. 1992:511135, 1992.
Iwasaki, Fumiaki et al. Japan Kokai Tokkyo Koho JP 06-145112, May 24, 1994; STN.RTM. CAPlus database, Accesision No. 1994;630348, 1994.

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