Nucleic acids encoding human tyrosine phosphatases

Details Nucleic acids encoding human tyrosine phosphatases Nucleic acids encoding human tyrosine phosphatases

1996-10-03

2000-02-01

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 235, 435 691, 435325, 4353201, 4352523, 43525411, C12N 916, C12N 1512

Patent

active

060201797

ABSTRACT:
The present invention provides novel human protein tyrosine phosphatases (HPTP) and polynucleotides which identify and encode HPTP. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPTP and for a method of producing HPTP. The invention also provides for pharmaceutical compositions comprising HPTP or antagonists of HPTP, and antibodies which specifically bind HPTP. Additionally, the invention provides antisense molecules to HPTP for treatment or prevention of diseases associated with abnormal expression of HPTP.

REFERENCES:
Charbonneau, H., et al., "1002 Protein Phosphatases?" Annu. Rev. Cell Biol., 8:463-93 (1992).
Diamond, R.H., et al., "PRL-1, a Unique Nuclear Protein Tyrosine Phosphatase, Affects Cell Growth" Mol. and Cell. Biol., 14:3752-3762 (1994).
Montagna, M., et al., "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase" Hum Genet, 96:532-538 (1995).
Hillier, L., et al., (GI 889096), GenBank Sequence Database (Accession H20401), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Crowell, P.L. et al., "Prenylation of novel oncogenic human PTP.sub.CAAX protein phosphatases", Abstract #3952, Proceedings of the American Association for Cancer Research, 1996.
Rommens, J.M. et al., "Generation of a Transcription Map at the HSD17B Locus Centromeric to BRCA1 at 17q21" Genomics (1995) 28:530-542.
Hillier, L. et al., (Accession Number N68341) EMBL Database, EMBL Database, Geneva, Switzerland.
Auffray, C. et al., (Accession Number Z43070) EMBL Database, EMBL Database, Geneva, Switzerland.
Cates, C.A. et al., "Prenylation of oncogenic human PTP.sub.CAAX protein tyrosine phosphatases" Cancer Letters (1996) 110:49-55.

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