Cytikine signal regulators

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 4352523, C12P 2106, C12N 500, C12N 120, C12N 1500

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active

060201657

ABSTRACT:
The invention provides human cytokine signal regulators (CKSR) and polynucleotides which identify and encode CKSR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CKSR.

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Ziemnicka-Kotula, D. et al., "Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton*", J. Biol. Chem. 273 (22): 13681-13692 (1998).
Kharitonenkov, A. et al., "A family of proteins that inhibit signalling through tyrosine kinase receptors", Nature 386: 181-186 (1997).
Biesova, Z. et al., (Direct Submission), GenBank Sequence Database (Accession 2245671), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 2245671), Jul. 2, 1997.
Kharitonenkov, A. et al., (Direct Submission), GenBank Sequence Database (Accession 2052058), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 2052058), May 14, 1997.

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