Method for resolution of D,L-alpha-phenethylamine with D(-)mande

Details Method for resolution of D,L-alpha-phenethylamine with D(-)mande Method for resolution of D,L-alpha-phenethylamine with D(-)mande

1989-09-18

1991-01-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07B 5700

Patent

active

049837710

ABSTRACT:
A process for recovering optically pure D(+)alpha-phenethylamine which comprises addition of the racemic mixture to a water/acid solution, and as a resolving agent, optically active D(-)mandelic acid. An optically pure D(+)alpha-PEA mandelate salt is formed, crystallized out of solution and washed with water. The salt is broken with sodium hydroxide, or a similar base, and the D(+)PEA liberated is extracted with toluene. The D(+) PEA recovered by vacuum distillation is recovered in high yield, shows high enantiomeric purity.

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