Process for preparing 2-aromatic-3-halobenzothiazepines

Details Process for preparing 2-aromatic-3-halobenzothiazepines Process for preparing 2-aromatic-3-halobenzothiazepines

1989-11-20

1991-01-08

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D28110

Patent

active

049837338

ABSTRACT:
2-Aromatic-3-HALobenzothizepines are prepared by reaction of a 2,3-dihydro-2-aromatic-3-hydroxybenzothiazepine with a thionyl HALide. For example, dl-cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy-1, 5-benzothiazzepin-4(5H)-one relfuxed with thionyl chloride can prepare E-2-(4-methoxyphenyl)-3-chloro-1,5-benzothiazepin-4(5H)-one in 66 percent yield.

REFERENCES:
patent: 3075968 (1963-01-01), Krapcho
patent: 3895006 (1975-07-01), Krapcho et al.
patent: 3983106 (1976-09-01), Krapcho et al.
March, "Advanced Organic Chemistry", (3rd Edition) (1985). pp. 382-384 (Wiley).

Affiliated with

Also associated with

Rating

Process for preparing 2-aromatic-3-halobenzothiazepines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 2-aromatic-3-halobenzothiazepines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 2-aromatic-3-halobenzothiazepines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-935845