Human JAK2 kinase

Details Human JAK2 kinase Human JAK2 kinase

1998-11-19

2000-02-01

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

435183, 435194, 530350, 530827, C07K 1447

Patent

active

060199660

ABSTRACT:
The present invention provides a polynucleotide (hjak2) which identifies and encodes a novel human Jak2 kinase (HJAK2) which was expressed in the placenta. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified HJAK2 peptide, antibodies capable of binding to HJAK2, inhibitors which bind to HJAK2 and pharmaceutical compositions based on HJAK2 specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered hjak2 expression and which allow identification of such a condition. These assays utilize probes which comprise oligomers, fragments, or portions of hjak2 or its regulatory elements or antibodies specifically binding HJAK2.

REFERENCES:
patent: 5716818 (1998-02-01), Wilks et al.
Kawamura et al. Moleculal Cloning of L-JAK, a Janus Family Protein-Tyrosine Kinase Expressed in Natural Killer Cells and Activated Leukocytes. Proc. Natl. Acad. Sci. USA 91:6374-6378, Jul. 1994.
Saltzman et al. Cloning and Characterization of Human JAK2 Kinase: High mRNA Expression in Immune Cells and Muscle Tissue. Biochem. Biophys. Res. Comm. 246: 627-633, May 1998.
Dalal et al. Cloning and Characterization of the Human Homolog of Mouse JAK2. Blood. 91(3): 844-851, Feb. 1998.
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Wilks, A .F., "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction," Proc. Nalt. Acad. Sci. USA, PNAS 86:1603-7 (1989).
Silvennoinen, B.A. et al., "Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction," Proc. Natl. Acad. Sci. USA, PNAS 90:8429-8433 (1993).
Nierman, et al., eds., ATCC/NIH Repository Catalog of Human and Mouse DNA Probes and Libraries, Eighth Edition, pp. 1-70.

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