Non-steroidal radiolabeled agonist/antagonist compounds and thei

Details Non-steroidal radiolabeled agonist/antagonist compounds and thei Non-steroidal radiolabeled agonist/antagonist compounds and thei

1998-06-04

2000-02-01

Powers, Fiona T.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 185, 424 189, 548231, 558413, 558414, 564162, 564170, 564202, A61K 5100

Patent

active

060199571

ABSTRACT:
The present invention relates to a radiolabeled non-steroidal compound having the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, are the same or different and are a radioactive or nonradioactive halogen, a nitro, a cyano, a carbamoyl, a hydrogen, a perfluoroalkyl, a haloalkylamido, an isothiocyanate, an azide, a diazocarbonyl, a substituted oxirane, or a .beta.-chloroethylamine;

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Tucker et al., "Resolution of the Nonsteriodal Antiandrogen 4'-Cyano-3-[4-fluorophenyl) sulfonyl]-2-hydroxy-2-methyl-3'-(trifluoromethyl)-propionanilide and the Determination of the Absolute Configuration of the Active Enantiomer," J. Med. Chem., 31(4):885-887 (1988).
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