Process for the production of 2-amino-4-hydroxy-6-methylpteridin

Details Process for the production of 2-amino-4-hydroxy-6-methylpteridin Process for the production of 2-amino-4-hydroxy-6-methylpteridin

1977-01-13

1978-06-13

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D47504

Patent

active

040948749

ABSTRACT:
The process for the production of 2-amino-4-hydroxy-6-methylpteridine from 2,4,5-triamine-6-hydroxypyrimidine and 1,1-dichloroacetone which is characterized in that the 2,4,5-triamino-6-hydroxypyrimidine in the form of one of its stable salts is converted with 1,1-dichloroacetone. The 1,1-dichloroacetone is present in a 1 to 2 equivalents ratio, based upon the 2,4,5-tiramino-6-hydroxypyrimidine, to 2-amino-4-hydroxy-6-methylpteridine. The conversion is conducted in a solvent at a pH of 3.5 to 4.5 in the presence of sodium bisulfite. From 1.2 mole of the sodium bisulfite per mole of the stable salt of 2,4,5-triamino-6-hydroxypyrimidine at 5 liters of reaction solution up to 3 moles of sodium bisulfite per mole of the stable salt of 2,4,5-triamino-6-hydroxypyrimide at 50 liters of reaction solution is used.

REFERENCES:
king et al., J. Chem. Soc., 1952 pp. 2144-2152.

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