Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1986-09-12
1991-01-08
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351721, 435 681, 435 691, 435188, 435 698, 435711, 935 47, 935 48, 935 49, C12P 2100, C12N 1500
Patent
active
049835211
ABSTRACT:
Novel DNA constructions are provided, as well as their expression products, involving the use of transmembrane integrator sequences joined from one to two open reading frames and optionally a signal sequence, particularly at the N-terminus. The DNA constructs when used with membranal translation systems provide for translocation of the peptides into the membrane. Alternatively, a signal sequence may be introduced internal to an open reading frame, where the resulting translation product may be processed by a membrane to provide two peptides.
REFERENCES:
Silhavy, T. J. (1977) PNAS 74:5411-5415.
Moreno et al., Nature 286:356 (1980).
Bassford et al., J. Bacteriol 139:19 (1979).
Talmadge et al., Nature 294:176 (1981).
Sabatini et al., J. Cell Biology 92:1-22 (1982).
Lingappa et al., Nature 281:117 (1979).
Lingappa Vishwanath R.
Yost Charles S.
Brown Anne
Rowland Bertram I.
Schwartz Richard A.
The Regents of the University of California
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