Method for detecting the antiaggregatory effect of vasoactive su

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 13, 435 19, 435 25, 435184, 436 63, 436 69, C12Q 102, C12Q 156

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049835149

ABSTRACT:
The antiaggregatory effect of phosphodiesterase inhibitors (A) and/or of cyclooxygenase inhibitors (B) is detected outside the human or animal body by

REFERENCES:
patent: 4051236 (1977-09-01), Harris et al.
patent: 4694024 (1987-09-01), Weithmann et al.
Smith, "Effect of Thromboxane Synthetase Inhibitors . . . ", Thrombosis Research, 28:477-485 (1982).
Born, G. V. R., "Aggregation of Blood Platelets by Adenosine Diphosphate and Its Reversal", Nature, 194:927-929 (1962).
Ingerman-Wojenski et al., "Evaluation of Electrical Aggregometry: Comparision with Optical Aggregometry, Secretion of ATP, and Accumulation of Radiolabeled Platelets", J. Lab. Clin. Med., 101:44-52 (1983).
M. Chignard et al., "The Role of Platelet-Activating Factor in Platelet Aggregation," Nature, vol. 279, 5716, pp. 799-800, (Jun. 28, 1979).
M. Kuchar and V. Rejholec, "Antithrombotic Agents," Drugs of the Future, vol. 11, No. 8, pp. 689-701 (1986).
Ser. No. 06/881,658 filed 07/03/1986 under Weithmann et al.

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