Process for the preparation of .alpha.-fluoroacryloyl derivative

Details Process for the preparation of .alpha.-fluoroacryloyl derivative Process for the preparation of .alpha.-fluoroacryloyl derivative

1990-08-13

1992-06-23

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560219, 562526, 568946, C07C 6730

Patent

active

051244764

ABSTRACT:
.alpha.-Fluoroacryloyl derivatives are prepared by reacting a dihalogenopropene with an anhydrous mixture of nitric acid and hydrofluoric acid to give a 1-nitro-2,2-fluorohalogeno-3-halogenopropane, converting this in the presence of a strong acid and a little water at elevated temperature to a 2,2-fluorohalogeno-3-halogenopropanoic acid, converting this into an ester or an amide and finally treating this with a dehalogenating agent.

REFERENCES:
patent: 152235 (1867-06-01), Knunyants et al.
patent: 4533776 (1985-08-01), Baasner et al.
patent: 4604482 (1986-08-01), Ohmori et al.
E. Earl Royals, Advanced Organic Chemistry .COPYRGT.1984 by Prentice-Hall, Inc. fourth printing, May 1959, p. 600.

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