Process for producing d,1-5-methyltetrahydrofolic acid and its s

Details Process for producing d,1-5-methyltetrahydrofolic acid and its s Process for producing d,1-5-methyltetrahydrofolic acid and its s

1978-07-10

1992-06-23

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D47504

Patent

active

051244527

ABSTRACT:
A method for preparing d,1-5-methyltetrahydrofolic acid and the salts thereof of the formula: ##STR1## wherein X is hydrogen, an alkaline metal or alkaline earth metal; by reduction of folic acid with sodium borohydride followed by the methylation of the tetrahydrofolic acid thus obtained with aqueous solutions of formaldehyde and sodium borohydride in an inert atmosphere.

REFERENCES:
patent: 3870719 (1975-03-01), Knott et al.
patent: 4148999 (1979-04-01), Temple et al.
patent: 4959472 (1990-09-01), Wood et al.
patent: 5006655 (1991-04-01), Mueller et al.
patent: 5010194 (1991-04-01), Mueller et al.

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