Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(sub

Details Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(sub Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(sub

1981-03-05

1983-06-28

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 27, A61K 31545, C07D50156

Patent

active

043905358

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or a (C.sub.1 -C.sub.4) alkyl group, X is a straight or branched chain C.sub.1 -C.sub.4 alkylene group and R.sub.2 is a carboxyl group or a sulfo group; and the pharmaceutically acceptable salts thereof exhibit strong inhibitory activities against a wide variety of Gram-positive and Gram-negative bacteria including Psendomonas aeruginosa, indolepositive Proteus and Enterobacter aerogenes, and also have an increased and prolonged serum level in a living body. The compounds are therefore useful as antibacterial agents for the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

REFERENCES:
patent: 4068074 (1978-01-01), Murakami et al.
patent: 4080498 (1978-03-01), Numata et al.
patent: 4156724 (1979-05-01), Yamada et al.
patent: 4165373 (1979-08-01), Yamada et al.

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