Bone morphogenetic protein process

Details Bone morphogenetic protein process Bone morphogenetic protein process

1980-08-04

1981-10-13

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260118, 2601237, 424 95, 424177, C07G 700

Patent

active

042947537

ABSTRACT:
The process of separating bone morphogenetic protein (BMP) from bone tissue comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone collagen to gelatin and extracting BMP into the solution of solubilizing agent; and separating the solubilizing agent and neutral salt from the solution, thereby precipitating BMP in the aqueous medium.

REFERENCES:
patent: 2384673 (1945-09-01), Greffie
patent: 2717835 (1955-09-01), Brody
patent: 3539549 (1970-11-01), Greenfield
patent: 3887717 (1975-06-01), Pfeiffer et al.
Proc. Nat. Acad. Sci. USA (1979), 76(4), pp. 1828-1832, Urist et al.
Proc. Soc. Exp. Bio. 2 Med. 162:48-53 (1979), Urist et al.

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