N-(pyrrol-1-yl)pyridinamines having memory enhancing properties

Details N-(pyrrol-1-yl)pyridinamines having memory enhancing properties N-(pyrrol-1-yl)pyridinamines having memory enhancing properties

1985-12-04

1988-06-21

Rothman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546281, C07D40102, A61K 3144

Patent

active

047526106

ABSTRACT:
There are disclosed novel compounds of the formula ##STR1## where R is H, loweralkyl, halogen, cyano, loweralkanoyl, arylloweralkanoyl, aroyl, --CH(OH)r.sub.1, --C(OH)r.sub.1 r.sub.2 or --CH.sub.2 Or.sub.2, where r.sub.1 is H, loweralkyl, arylloweralkyl or aryl and r.sub.2 is loweralkyl; R.sub.1 is H, loweralkyl, arylloweralkyl, phenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, aminophenyl, loweralkanoylaminophenyl, loweralkoxycarbonyl, arylloweralkoxycarbonyl, aryloxycarbonyl, loweralkylaminocarbonyl, arylloweralkylaminocarbonyl, arylaminocarbonyl, alkanoyl, arylloweralkanoyl, aroyl, alkenoyl or alkynoyl; and R.sub.2 is H, NO.sub.2, NH.sub.2, halogen, loweralkanoylamino, arylloweralkanoylamino, aroylamino or loweralkyl, or R.sub.2 as a whole is a combination of 2, 3 or 4 halogen atoms; or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory, methods for synthesizing them, pharmaceutical compositions comprising an effective memory enhancing amount of such a compound and methods of treating a patient in need of memory enhancement by administering such a compound to the patient.

REFERENCES:
patent: 4631286 (1986-12-01), Shutske et al.
patent: 4670562 (1987-06-01), Martin et al.
patent: 4695573 (1987-09-01), Shutske et al.
USA Today, Thursday, Jul. 9, 1987, Life Section, article on No Alzheimer Test.

Affiliated with

Also associated with

Rating

N-(pyrrol-1-yl)pyridinamines having memory enhancing properties does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-(pyrrol-1-yl)pyridinamines having memory enhancing properties, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-(pyrrol-1-yl)pyridinamines having memory enhancing properties will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-930079