Expression of .alpha.-1 antitrypsin in yeast

Details Expression of .alpha.-1 antitrypsin in yeast Expression of .alpha.-1 antitrypsin in yeast

1984-06-14

1988-06-21

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435255, 435320, 435 70, 935 37, 935 60, 935 69, 935 97, C12P 2100, C12P 2102, C12N 116, C12N 100

Patent

active

047525762

ABSTRACT:
Methods and compositions are provided for high level production of foreign proteins in yeast. The system is exemplified by production of .alpha..sub.1 -antitrypsin in yeast strain AB110, derived from yeast strains 2150-2-3 and AB103.1.
S. carlsbergensis/S. cerevisiae hybrid strain AB110 containing plasmid pCl/1GAPATi9 was deposited at the A.T.C.C. on May 9, 1984, and given Accession No. 20709.

REFERENCES:
patent: 4599311 (1986-07-01), Kawasaki
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Cai, J. et al, Biological Abstracts 75(11):79940, 1982.
Courtney et al., Proc. Natl. Acad. Sci. USA (1984), 81:699-673.
Kawasaki et al., "The Production of Human Alpha-1 Antitrypsin in Yeast", in the Molecular Biology of Yeast, p. 230 (Cold Spring Harbor Laboratory 1983).
Russell et al., "Expression of Human Alpha-1 Antitrypsin in Fission Yeast", ibid, p. 231.
Carrell et al., Nature (1982), 298329-334.
Kurachi et al., Proc. Natl. Acad. Sci. USA (1981), 78:6826-6830.
Bollen et al., DNA (1983), 2:255-264.

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