Physiologically active derivatives of esterastin

Details Physiologically active derivatives of esterastin Physiologically active derivatives of esterastin

1979-04-26

1980-05-13

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435123, 435886, C07D30512

Patent

active

042028248

ABSTRACT:
Three, new physiologically active derivatives of esterastin are now provided, which inhibit the activity of esterase similarly to the parent esterastin and further exhibit a higher inhibiting activity against cholesterol esterase than the parent esterastin. These three new derivatives are tetrahydroesterastin which is produced by catalytic hydrogenation of esterastin; 3,5-di-hydroxy-2-hexylhexadeca-7,10-dienoic 1,3-lactone which is produced by alkaline hydrolysis of esterastin; and 3,5-di-hydroxy-2-hexylhexadecanoic 1,3-lactone which is produced either by alkaline hydrolysis of said tetrahydroesterastin or by catalytic hydrogenation of the product of the alkaline hydrolysis of esterastin.

REFERENCES:
Umezawa et al., The Journal of Antibiotics 31, No. 6, 639-641 (Jun. 1978).
Kondo et al., The Journal of Antibiotics 31, No. 8, 797-800 (Aug. 1978).

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