Peptides related to somatostatin

Details Peptides related to somatostatin Peptides related to somatostatin

1978-10-02

1980-05-13

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125S, 424177, C08L 8900, C07C10352, A61K 3700

Patent

active

042028027

ABSTRACT:
The tetradecapeptides of the formula ##STR1## wherein X is H--Ala--D--Ala, H--D--Ala--Gly, or H--D--Val--Gly; and X is Ala--Leu, Ala--Phe, Ala--D--Phe, D--Ala--Phe, or D--Ala--Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.

REFERENCES:
patent: 3904594 (1975-09-01), Guillemin et al.

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