Process for substituted 5-benzyl-2,4-diamino-pyrimidines

Details Process for substituted 5-benzyl-2,4-diamino-pyrimidines Process for substituted 5-benzyl-2,4-diamino-pyrimidines

1977-06-10

1979-03-06

Tovar, Jose

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, C07D23948, A61K 31505

Patent

active

041432274

ABSTRACT:
A process for preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower alkoxy or taken together are METHYLENEDIOXY; R.sub.3 is lower alkyl or hydrogen, which comprises the step of reacting an aromatic compound of the formula ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as previously described, with a diamino-pyrimidine of the formula ##STR3## wherein R.sub.4 is lower alkoxy, benzyloxy, hydroxy or halogen, in the presence of an inorganic or organic acid selected from the group consisting of ortho-phosphoric acid, poly-phosphoric acid, hydrohalic acids and tri-haloacetic acids, at a temperature in the range of from about 50.degree. C. to about 110.degree. C., is described.

REFERENCES:
patent: 3485840 (1969-12-01), Hoffer
Wagner, et al., Synthetic Organic Chemistry, 1953, John Wiley & Sons, Inc. pp. 2-3.

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