Preparation of imidazoles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D23358

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047193093

ABSTRACT:
Imidazoles are prepared by subjecting an .alpha.,.beta.-dicarbonyl compound to a Radziszewski reaction with an aldehyde and ammonia and then catalytically hydrogenating the product.
Imidazole and its derivatives are useful intermediates for drugs, crop protection agents and dyes.

REFERENCES:
K. Hofmann, The Chemistry of Heretocyclic Compounds, Imidazole and Its Derivatives, Part I, p. 33 (1953).

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